منابع مشابه
Fragile X-related proteins regulate mammalian circadian behavioral rhythms.
Fragile X syndrome results from the absence of the fragile X mental retardation 1 (FMR1) gene product (FMRP). FMR1 has two paralogs in vertebrates: fragile X related gene 1 and 2 (FXR1 and FXR2). Here we show that Fmr1/Fxr2 double knockout (KO) and Fmr1 KO/Fxr2 heterozygous animals exhibit a loss of rhythmic activity in a light:dark (LD) cycle, and that Fmr1 or Fxr2 KO mice display a shorter fr...
متن کاملCircadian rhythms.
1997 marks the 25th anniversary of the discovery of the master circadian pacemaker in mammals in the hypothalamic suprachiasmatic nucleus. Remarkable progress has been made over the last 25 years in elucidating the physiological mechanisms involved in the entrainment, generation and expression of circadian rhythms at the cellular and systems levels. The recent discovery and cloning of the first...
متن کاملCircadian rhythms.
Circadian rhythms are a ubiquitous adaptation of eukaryotic organisms to the most reliable and predictable of environmental changes, the daily cycles of light and temperature. Prominent daily rhythms in behavior, physiology, hormone levels and biochemistry (including gene expression) are not merely responses to these environmental cycles, however, but embody the organism's ability to keep and t...
متن کاملCircadian rhythms and reproduction.
There is a growing recognition that the circadian timing system, in particular recently discovered clock genes, plays a major role in a wide range of physiological systems. Microarray studies, for example, have shown that the expression of hundreds of genes changes many fold in the suprachiasmatic nucleus, liver heart and kidney. In this review, we discuss the role of circadian rhythmicity in t...
متن کاملCircadian Rhythms 148.qxp
RAPID TRANSMERIDIAN TRAVEL CAN PRODUCE JET LAG, WHICH IS CHARACTERIZED BY A CONSTELLATION OF SYMPTOMS, INCLUDING POOR NIGHTTIME SLEEP, INCREASED DAYTIME SLEEPINESS, DECREASED ALERTNESS, IMPAIRED PERFORMANCE, FATIGUE, IRRITABILITY, DEPRESSED MOOD, AND GASTROINTESTINAL DISTRESS.1-5 It is caused by a temporary misalignment between the endogenous circadian clock and the desired destination sleep/wa...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Bone
سال: 2013
ISSN: 8756-3282
DOI: 10.1016/j.bone.2013.02.011